Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM484149
Substrate
n/a
Meas. Tech.
Radioligand Assay
Ki
<100±n/a nM
Citation
 Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C Oxadiazaspiro compounds for the treatment of drug abuse and addiction US Patent  US11649248 Publication Date 5/16/2023 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM484149
Synonyms:
(R)-4-ethyl-9-(4- fluorobenzyl)-2-methyl-1-oxa- 4,9-diazaspiro[5.5]undecan- 3-one | US10927128, Example 70 | US11649248, Example 70
Type:
Small organic molecule
Emp. Form.:
C18H25FN2O2
Mol. Mass.:
320.4017
SMILES:
CCN1CC2(CCN(Cc3ccc(F)cc3)CC2)O[C@H](C)C1=O |r|
Structure:
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