Reaction Details Report a problem with these data
Target
Discoidin domain-containing receptor 2
Ligand
BDBM603905
Substrate
n/a
Meas. Tech.
Enzyme-linked immunosorbent assay (ELISA)
IC50
0.300±n/a nM
Citation
 Xiong, B; Li, J; Geng, M; Shen, J; Zang, Y; Ai, J; Chen, D; Wang, Q; Dong, Y; Peng, X; Ji, Y; Tan, Q Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof US Patent  US11655239 Publication Date 5/23/2023 
Target
Name:
Discoidin domain-containing receptor 2
Synonyms:
DDR2 | DDR2_HUMAN | Discoidin domain receptor 2 (DDR2) | Discoidin domain-containing receptor 2 | Discoidin domain-containing receptor 2 (DDR2) | Epithelial discoidin domain-containing receptor 2 (DDR2) | NTRKR3 | TKT | TYRO10
Type:
Protein
Mol. Mass.:
96717.07
Organism:
Homo sapiens (Human)
Description:
Q16832
Residue:
855
Sequence:
MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE
  
Inhibitor
Name:
BDBM603905
Synonyms:
US11655239, Compound S19
Type:
Small organic molecule
Emp. Form.:
C34H29F3N6O
Mol. Mass.:
594.6289
SMILES:
FC(F)(F)c1cccc(c1)C1(CC1)NC(=O)c1ccc(C2CC2)c(c1)-c1ccc2nc(Nc3cnn(c3)C3CC3)ncc2c1
Structure:
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