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Target
Tyrosine-protein phosphatase non-receptor type 1 [1-405]
Ligand
BDBM50481947
Substrate
n/a
Meas. Tech.
Metabolic Measurements
Ki
8000±n/a nM
Citation
 Tonks, N; Krishnan, N Treatment of Rett syndrome US Patent  US11660306 Publication Date 5/30/2023 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1 [1-405]
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1
Type:
n/a
Mol. Mass.:
46535.71
Organism:
Homo sapiens (Human)
Description:
P18031[1-405]
Residue:
405
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSY
  
Inhibitor
Name:
BDBM50481947
Synonyms:
CHEBI:8416 | GNF-Pf-476 | PRISTIMERIN | Pristimerine | US11660306, Example Pristimerin | acs.jmedchem.1c00409_ST.332
Type:
Small organic molecule
Emp. Form.:
C30H40O4
Mol. Mass.:
464.6362
SMILES:
[H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(=O)OC |r,c:24,t:14,16,19|
Structure:
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