Reaction Details Report a problem with these data
Target
Hepatocyte growth factor receptor [974-1390,A1209G,V1290L]
Ligand
BDBM605720
Substrate
n/a
Meas. Tech.
Human Met Kinase Assay
IC50
<10±n/a nM
Citation
 Bannen, LC; Bui, M; Jiang, F; Wang, Y; Xu, W Compounds for the treatment of kinase-dependent disorders US Patent  US11673897 Publication Date 6/13/2023 
Target
Name:
Hepatocyte growth factor receptor [974-1390,A1209G,V1290L]
Synonyms:
Hepatocyte growth factor receptor (R974-S1390) (A1209G) (V1290L) | MET | MET_HUMAN
Type:
Protein
Mol. Mass.:
46809.96
Organism:
Homo sapiens (Human)
Description:
P08581[974-1390,A1209G,V1290L]
Residue:
417
Sequence:
RVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARGCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTLDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM605720
Synonyms:
US11673897, Compound 10 | methyl 4-[5-[[1-[(4- fluorophenyl)carbamoyl]cyclo- propanecarbonyl]amino]pyridin-2- yl]oxy-7-methoxyquinoline-6- carboxylate
Type:
Small organic molecule
Emp. Form.:
C28H23FN4O6
Mol. Mass.:
530.5038
SMILES:
COC(=O)c1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cn3)ccnc2cc1OC
Structure:
Search PDB for entries with ligand similarity: