Reaction Details Report a problem with these data
Target
Hepatocyte growth factor receptor [974-1390,A1209G,V1290L]
Ligand
BDBM605728
Substrate
n/a
Meas. Tech.
Human Met Kinase Assay
IC50
55±n/a nM
Citation
 Bannen, LC; Bui, M; Jiang, F; Wang, Y; Xu, W Compounds for the treatment of kinase-dependent disorders US Patent  US11673897 Publication Date 6/13/2023 
Target
Name:
Hepatocyte growth factor receptor [974-1390,A1209G,V1290L]
Synonyms:
Hepatocyte growth factor receptor (R974-S1390) (A1209G) (V1290L) | MET | MET_HUMAN
Type:
Protein
Mol. Mass.:
46809.96
Organism:
Homo sapiens (Human)
Description:
P08581[974-1390,A1209G,V1290L]
Residue:
417
Sequence:
RVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARGCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTLDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM605728
Synonyms:
1-N'-[5-chloro-6-[(6,7-dimethoxy- 1,5-naphthyridin-4-yl)oxy]pyridin- 3-yl]-1-N-(4- fluorophenyl)cyclopropane-1,1- dicarboxamide | US11673897, Compound 80
Type:
Small organic molecule
Emp. Form.:
C26H21ClFN5O5
Mol. Mass.:
537.927
SMILES:
COc1cc2nccc(Oc3ncc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3Cl)c2nc1OC
Structure:
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