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Target
Tyrosine-protein kinase JAK2 [Y1007F,Y1008F]
Ligand
BDBM607891
Substrate
n/a
Meas. Tech.
JAK2 Binding Assay
Kd
<10±n/a nM
Citation
 Masse, CE; Greenwood, JR; Mondal, S; Xu, J; Ghanakota, P; McRobb, FM; Boyles, N 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors US Patent  US11691963 Publication Date 7/4/2023 
Target
Name:
Tyrosine-protein kinase JAK2 [Y1007F,Y1008F]
Synonyms:
Tyrosine-protein kinase JAK2 (Y1007F, Y1008F)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
130652.68
Organism:
Homo sapiens (Human)
Description:
O60674[Y1007F,Y1008F]
Residue:
1132
Sequence:
MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLGMAVLDMMRIAKENDQTPLAIYNSISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFSQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEFFKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM607891
Synonyms:
US11691963, Example I-62
Type:
Small organic molecule
Emp. Form.:
C25H23N7O3
Mol. Mass.:
469.4952
SMILES:
CC(=O)Nc1cc(Oc2ccc3nc(Nc4cc(cn(C)c4=O)C4CC4)n(C)c3c2C#N)ccn1
Structure:
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