Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Ligand
BDBM608340
Substrate
n/a
Meas. Tech.
Inhibition of Mcl-1 by fluorescence polarization (FP) assay
IC50
14.0±n/a nM
Citation
 Chen, H; Chen, W; Li, C; Li, D; Jing, Y; Tang, G; Zhou, Y; Wang, S; Yang, C Macrocyclic indoles as Mcl-1 inhibitors US Patent  US11691989 Publication Date 7/4/2023 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Synonyms:
Induced myeloid leukemia cell differentiation protein Mcl-1 (171-323)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17540.76
Organism:
Homo sapiens (Human)
Description:
Q07820[171-323]
Residue:
153
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED
  
Inhibitor
Name:
BDBM608340
Synonyms:
US11691989, Compound 2 | Z)-15-chloro-96-fluoro-13,61-dimethyl-25,26- dihydro-11H,24H,61H-10-oxa-4,8-dithia- 1(4,1)-indola-2(3,2)-pyrrolo[1,2-b]pyrazola- 6(3,5)-pyrazola-9(3,1)- naphthalenacyclotridecaphane-12-carboxylic acid
Type:
Small organic molecule
Emp. Form.:
C36H33ClFN5O3S2
Mol. Mass.:
702.26
SMILES:
Cc1c(C(O)=O)n2CCCOc3cc(SCc4cc(CSCc5nn6CCCc6c5-c5c(Cl)ccc2c15)nn4C)cc1cc(F)ccc31
Structure:
Search PDB for entries with ligand similarity: