Reaction Details Report a problem with these data
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Ligand
BDBM608370
Substrate
n/a
Meas. Tech.
Inhibition of Mcl-1 by fluorescence polarization (FP) assay
IC50
14.0±n/a nM
Citation
 Chen, H; Chen, W; Li, C; Li, D; Jing, Y; Tang, G; Zhou, Y; Wang, S; Yang, C Macrocyclic indoles as Mcl-1 inhibitors US Patent  US11691989 Publication Date 7/4/2023 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-323]
Synonyms:
Induced myeloid leukemia cell differentiation protein Mcl-1 (171-323)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17540.76
Organism:
Homo sapiens (Human)
Description:
Q07820[171-323]
Residue:
153
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVED
  
Inhibitor
Name:
BDBM608370
Synonyms:
US11691989, Compound 26 | Z)-15-chloro-13,23,61-trimethyl-21-(2- (methylamino)-2-oxoethyl)-11H,21H,61H-10- oxa-4,8-dithia-1(4,1)-indola-2(4,5),6(3,5)- dipyrazola-9(3,1)- naphthalenacyclotridecaphane-12-carboxylic acid
Type:
Small organic molecule
Emp. Form.:
C37H37ClN6O4S2
Mol. Mass.:
729.31
SMILES:
CNC(=O)Cn1nc(C)c-2c1CSCc1cc(CSc3cc(OCCCn4c(C(O)=O)c(C)c5c-2c(Cl)ccc45)c2ccccc2c3)n(C)n1
Structure:
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