Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [349-460]
Ligand
BDBM391509
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<100±n/a nM
Citation
 Combs, AP; Maduskuie, Jr., TP; Falahatpisheh, N 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins US Patent  US11702416 Publication Date 7/18/2023 
Target
Name:
Bromodomain-containing protein 4 [349-460]
Synonyms:
BRD4 | BRD4 bromodomain 2 | BRD4_HUMAN | Brd4-2 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13087.06
Organism:
Homo sapiens (Human)
Description:
O60885[349-460]
Residue:
112
Sequence:
KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM391509
Synonyms:
US10472358, Example 9B | US10781209, Example 9 | US11059821, Example 9 | US11702416, Example 9 | US9957268, Example 9 | US9957268, Example 9A | US9957268, Example 9B
Type:
Small organic molecule
Emp. Form.:
C20H21N3O4
Mol. Mass.:
367.3984
SMILES:
COc1cc2NC(=O)C(Oc2c(c1)-c1cn(C)c(=O)c2[nH]ccc12)C(C)C
Structure:
Search PDB for entries with ligand similarity: