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Target
Bromodomain-containing protein 4 [349-460]
Ligand
BDBM391594
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<100±n/a nM
Citation
 Combs, AP; Maduskuie, Jr., TP; Falahatpisheh, N 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins US Patent  US11702416 Publication Date 7/18/2023 
Target
Name:
Bromodomain-containing protein 4 [349-460]
Synonyms:
BRD4 | BRD4 bromodomain 2 | BRD4_HUMAN | Brd4-2 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13087.06
Organism:
Homo sapiens (Human)
Description:
O60885[349-460]
Residue:
112
Sequence:
KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM391594
Synonyms:
6-acetyl-2,2,4-trimethyl-8-(6- methyl-7-oxo-6,7-dihydro- 1H-pyrrolo[2,3-c]pyridin-4- yl)-2H-1,4-benzoxazin-3(4H)- one | US10472358, Example 82 | US10781209, Example 82 | US11059821, Example 82 | US11702416, Example 82 | US9957268, Example 82
Type:
Small organic molecule
Emp. Form.:
C21H21N3O4
Mol. Mass.:
379.4091
SMILES:
CN1C(=O)C(C)(C)Oc2c1cc(cc2-c1cn(C)c(=O)c2[nH]ccc12)C(C)=O
Structure:
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