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Target
Son of sevenless homolog 1 [564-1049]
Ligand
BDBM609526
Substrate
n/a
Meas. Tech.
Inhibiting SOS1-Mediated GTP Nucleotide Exchange by Blocking Mant-GDP Exchange
IC50
12.0±n/a nM
Citation
 Marx, MA; Ketcham, JM; Smith, CR; Lawson, JD; Burns, AC; Wang, X; Kulyk, S; Ivetac, A SOS1 inhibitors US Patent  US11702418 Publication Date 7/18/2023 
Target
Name:
Son of sevenless homolog 1 [564-1049]
Synonyms:
SOS1 | SOS1_HUMAN | Son of sevenless homolog 1 (SOS1)(564-1049)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56970.22
Organism:
n/a
Description:
aa 564-1049
Residue:
486
Sequence:
EEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT
 
Inhibitor
Name:
BDBM609526
Synonyms:
US11702418, Example 11-5
Type:
Small organic molecule
Emp. Form.:
C28H32F3N5O2
Mol. Mass.:
527.5812
SMILES:
C[C@@H](Nc1nnc(C)c2ccc(cc12)N1CCN(CC1)C(=O)[C@H]1CCOC1)c1cccc(c1C)C(F)(F)F |r|
Structure:
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