Reaction Details Report a problem with these data
Target
Hepatocyte growth factor receptor [974-1390,A1209G,V1290L]
Ligand
BDBM609979
Substrate
n/a
Meas. Tech.
Human KDR Kinase Assay
IC50
550±n/a nM
Citation
 Bannen, LC; Bui, M; Jiang, F; Wang, Y; Xu, W Compounds for the treatment of kinase-dependent disorders US Patent  US11708367 Publication Date 7/25/2023 
Target
Name:
Hepatocyte growth factor receptor [974-1390,A1209G,V1290L]
Synonyms:
Hepatocyte growth factor receptor (R974-S1390) (A1209G) (V1290L) | MET | MET_HUMAN
Type:
Protein
Mol. Mass.:
46809.96
Organism:
Homo sapiens (Human)
Description:
P08581[974-1390,A1209G,V1290L]
Residue:
417
Sequence:
RVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARGCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTLDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM609979
Synonyms:
1-N-[4-(7-chloropyrido[3,2- d]pyrimidin-4-yl)oxyphenyl]- 1-N'-(4-fluorophenyl)cyclo- propane-1,1-dicarboxamide | US11708367, Compound 12
Type:
Small organic molecule
Emp. Form.:
C24H17ClFN5O3
Mol. Mass.:
477.875
SMILES:
Fc1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(Oc3ncnc4cc(Cl)cnc34)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: