Reaction Details Report a problem with these data
Target
Hepatocyte growth factor receptor [974-1390,A1209G,V1290L]
Ligand
BDBM609993
Substrate
n/a
Meas. Tech.
Human KDR Kinase Assay
IC50
<10±n/a nM
Citation
 Bannen, LC; Bui, M; Jiang, F; Wang, Y; Xu, W Compounds for the treatment of kinase-dependent disorders US Patent  US11708367 Publication Date 7/25/2023 
Target
Name:
Hepatocyte growth factor receptor [974-1390,A1209G,V1290L]
Synonyms:
Hepatocyte growth factor receptor (R974-S1390) (A1209G) (V1290L) | MET | MET_HUMAN
Type:
Protein
Mol. Mass.:
46809.96
Organism:
Homo sapiens (Human)
Description:
P08581[974-1390,A1209G,V1290L]
Residue:
417
Sequence:
RVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARGCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTLDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM609993
Synonyms:
1-N'-[3-chloro-4-[6-methoxy- 7-(3-morpholin-4- ylpropoxy)pyrido[3,2- d]pyrimidin-4-yl]oxyphenyl]- 1-N-(4-fluorophenyl)cyclo- propane-1,1-dicarboxamide | US11708367, Compound 66
Type:
Small organic molecule
Emp. Form.:
C32H32ClFN6O6
Mol. Mass.:
651.084
SMILES:
COc1nc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3Cl)ncnc2cc1OCCCN1CCOCC1
Structure:
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