Reaction Details Report a problem with these data
Target
Hepatocyte growth factor receptor [974-1390,A1209G,V1290L]
Ligand
BDBM610010
Substrate
n/a
Meas. Tech.
Human KDR Kinase Assay
IC50
55±n/a nM
Citation
 Bannen, LC; Bui, M; Jiang, F; Wang, Y; Xu, W Compounds for the treatment of kinase-dependent disorders US Patent  US11708367 Publication Date 7/25/2023 
Target
Name:
Hepatocyte growth factor receptor [974-1390,A1209G,V1290L]
Synonyms:
Hepatocyte growth factor receptor (R974-S1390) (A1209G) (V1290L) | MET | MET_HUMAN
Type:
Protein
Mol. Mass.:
46809.96
Organism:
Homo sapiens (Human)
Description:
P08581[974-1390,A1209G,V1290L]
Residue:
417
Sequence:
RVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARGCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTLDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
  
Inhibitor
Name:
BDBM610010
Synonyms:
1-N'-(4-fluorophenyl)-1-N- [4-[7-methoxy-6-(2-pyrrolidin- 1-ylethyl- carbamoyl)quinazolin-4- yl]oxyphenyl]cyclopropane- 1,1-dicarboxamide | US11708367, Compound 118
Type:
Small organic molecule
Emp. Form.:
C33H33FN6O5
Mol. Mass.:
612.6507
SMILES:
COc1cc2ncnc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1C(=O)NCCN1CCCC1
Structure:
Search PDB for entries with ligand similarity: