Reaction Details Report a problem with these data
Target
Solute carrier family 13 member 5
Ligand
BDBM610837
Substrate
n/a
Meas. Tech.
Assay of the Citric Acid Cycle Activation
EC50
580±n/a nM
Citation
 Sato, S; Matsuda, S; Matsumura, C; Itotani, M; Shinohara, T; Fujita, S; Sakurai, Y; Tai, K; Fukushima, T; Kanemoto, N; Okamoto, T Cyanotriazole compounds US Patent  US10626095 Publication Date 4/21/2020 
Target
Name:
Solute carrier family 13 member 5
Synonyms:
NACT | Na(+)/citrate cotransporter | S13A5_HUMAN | SLC13A5 | Sodium-coupled citrate transporter | Sodium-dependent citrate transporter | Solute carrier family 13 member 5
Type:
PROTEIN
Mol. Mass.:
63069.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116736
Residue:
568
Sequence:
MASALSYVSKFKSFVILFVTPLLLLPLVILMPAKFVRCAYVIILMAIYWCTEVIPLAVTSLMPVLLFPLFQILDSRQVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEATSAATEAGLELVDKGKAKELPGSQVIFEGPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSWGCGLESKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILWFSRDPGFMPGWLTVAWVEGETKYVSDATVAIFVATLLFIVPSQKPKFNFRSQTEEERKTPFYPPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWANVTHIET
  
Inhibitor
Name:
BDBM610837
Synonyms:
US10626095, Example 142
Type:
Small organic molecule
Emp. Form.:
C19H16F3N5O
Mol. Mass.:
387.3584
SMILES:
CCC(OCc1ccc(cc1)C(F)(F)F)c1cccc(n1)-c1nn[nH]c1C#N
Structure:
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