Reaction Details Report a problem with these data
Target
Apelin
Ligand
BDBM610896
Substrate
n/a
Meas. Tech.
Measurement of Apelin Receptor Agonist Activity
EC50
18.0±n/a nM
Citation
 Ikeda, T; Kobayashi, Y; Miyoshi, N; Suzuki, O; Nagayama, T; Tsuji, T; Smith, LH; Pinkerton, AB Azole derivatives as apelin receptor agonist US Patent  US10626096 Publication Date 4/21/2020 
Target
Name:
Apelin
Synonyms:
APEL | APEL_HUMAN | APJ endogenous ligand | APLN | Apelin-13 | Apelin-28 | Apelin-31 | Apelin-36
Type:
PROTEIN
Mol. Mass.:
8579.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108275
Residue:
77
Sequence:
MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
  
Inhibitor
Name:
BDBM610896
Synonyms:
(2E)-3-[4-(2,6-Dimethoxyphenyl)-5-(5-methylfuran-2-yl)-4H-1,2,4-triazol-3-yl]prop-2-enoic acid | US10626096, Example 9
Type:
Small organic molecule
Emp. Form.:
C18H17N3O5
Mol. Mass.:
355.3447
SMILES:
COc1cccc(OC)c1-n1c(\C=C\C(O)=O)nnc1-c1ccc(C)o1 |(5.43,-.21,;3.89,-.21,;3.12,-1.54,;3.89,-2.88,;3.12,-4.21,;1.58,-4.21,;.81,-2.88,;-.73,-2.88,;-1.5,-4.21,;1.58,-1.54,;.81,-.21,;-.73,-.21,;-1.82,-1.3,;-3.3,-.9,;-4.39,-1.99,;-5.88,-1.59,;-3.99,-3.47,;-1.2,1.26,;.04,2.16,;1.29,1.26,;2.78,1.66,;4.02,.75,;5.27,1.66,;4.79,3.12,;5.88,4.21,;3.25,3.12,)|
Structure:
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