Reaction Details Report a problem with these data
Target
Apelin
Ligand
BDBM610909
Substrate
n/a
Meas. Tech.
Measurement of Apelin Receptor Agonist Activity
EC50
87.0±n/a nM
Citation
 Ikeda, T; Kobayashi, Y; Miyoshi, N; Suzuki, O; Nagayama, T; Tsuji, T; Smith, LH; Pinkerton, AB Azole derivatives as apelin receptor agonist US Patent  US10626096 Publication Date 4/21/2020 
Target
Name:
Apelin
Synonyms:
APEL | APEL_HUMAN | APJ endogenous ligand | APLN | Apelin-13 | Apelin-28 | Apelin-31 | Apelin-36
Type:
PROTEIN
Mol. Mass.:
8579.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108275
Residue:
77
Sequence:
MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
  
Inhibitor
Name:
BDBM610909
Synonyms:
US10626096, Example 22
Type:
Small organic molecule
Emp. Form.:
C19H21N3O5S
Mol. Mass.:
403.452
SMILES:
COc1cccc(OC)c1-n1c(SCCCC(O)=O)nnc1-c1ccc(C)o1 |(-.34,-4.17,;.43,-2.84,;1.97,-2.84,;2.74,-4.17,;4.28,-4.17,;5.05,-2.84,;4.28,-1.5,;5.05,-.17,;6.59,-.17,;2.74,-1.5,;1.97,-.17,;.44,-.01,;-.59,-1.15,;-2.1,-.83,;-3.13,-1.98,;-4.63,-1.66,;-5.66,-2.8,;-7.17,-2.48,;-5.19,-4.27,;.12,1.5,;1.46,2.27,;2.6,1.24,;4.06,1.71,;5.31,.81,;6.56,1.71,;6.08,3.18,;7.17,4.27,;4.54,3.18,)|
Structure:
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