Reaction Details Report a problem with these data
Target
Apelin
Ligand
BDBM610939
Substrate
n/a
Meas. Tech.
Measurement of Apelin Receptor Agonist Activity
EC50
217±n/a nM
Citation
 Ikeda, T; Kobayashi, Y; Miyoshi, N; Suzuki, O; Nagayama, T; Tsuji, T; Smith, LH; Pinkerton, AB Azole derivatives as apelin receptor agonist US Patent  US10626096 Publication Date 4/21/2020 
Target
Name:
Apelin
Synonyms:
APEL | APEL_HUMAN | APJ endogenous ligand | APLN | Apelin-13 | Apelin-28 | Apelin-31 | Apelin-36
Type:
PROTEIN
Mol. Mass.:
8579.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108275
Residue:
77
Sequence:
MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
  
Inhibitor
Name:
BDBM610939
Synonyms:
2-{(E)-2-[4-(2,6-Dimethoxyphenyl)-5-(5-methylfuran-2-yl)-4H-1,2,4-triazol-3-yl]ethenyl}-7-methyl-4H-pyrido[1,2-a]pyrimidin-4-one | US10626096, Example 52
Type:
Small organic molecule
Emp. Form.:
C26H23N5O4
Mol. Mass.:
469.4919
SMILES:
COc1cccc(OC)c1-n1c(\C=C\c2cc(=O)n3cc(C)ccc3n2)nnc1-c1ccc(C)o1 |(6.79,1.42,;5.25,1.42,;4.48,.08,;5.25,-1.25,;4.48,-2.58,;2.94,-2.58,;2.17,-1.25,;.63,-1.25,;-.14,-2.58,;2.94,.08,;2.17,1.42,;.63,1.42,;-.14,.08,;-1.63,.48,;-2.72,-.61,;-4.21,-.21,;-5.3,-1.3,;-6.79,-.9,;-4.9,-2.78,;-5.99,-3.87,;-5.59,-5.36,;-6.68,-6.45,;-4.1,-5.76,;-3.01,-4.67,;-3.41,-3.18,;-2.32,-2.09,;.15,2.88,;1.4,3.79,;2.64,2.88,;3.97,3.65,;5.22,2.75,;6.47,3.65,;5.99,5.12,;6.76,6.45,;4.45,5.12,)|
Structure:
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