Reaction Details Report a problem with these data
Target
Apelin
Ligand
BDBM610964
Substrate
n/a
Meas. Tech.
Measurement of Apelin Receptor Agonist Activity
EC50
158±n/a nM
Citation
 Ikeda, T; Kobayashi, Y; Miyoshi, N; Suzuki, O; Nagayama, T; Tsuji, T; Smith, LH; Pinkerton, AB Azole derivatives as apelin receptor agonist US Patent  US10626096 Publication Date 4/21/2020 
Target
Name:
Apelin
Synonyms:
APEL | APEL_HUMAN | APJ endogenous ligand | APLN | Apelin-13 | Apelin-28 | Apelin-31 | Apelin-36
Type:
PROTEIN
Mol. Mass.:
8579.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108275
Residue:
77
Sequence:
MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
  
Inhibitor
Name:
BDBM610964
Synonyms:
4-(2,6-Dimethoxyphenyl)-3-(5-methylfuran-2-yl)-5-[(1,3-thiazol-2-ylmethyl)sulfanyl]-4H-1,2,4-triazole | US10626096, Example 76
Type:
Small organic molecule
Emp. Form.:
C19H18N4O3S2
Mol. Mass.:
414.501
SMILES:
COc1cccc(OC)c1-n1c(SCc2nccs2)nnc1-c1ccc(C)o1 |(5.97,-.37,;4.43,-.37,;3.66,-1.7,;4.43,-3.04,;3.66,-4.37,;2.12,-4.37,;1.35,-3.04,;-.19,-3.04,;-.96,-4.37,;2.12,-1.7,;1.35,-.37,;-.19,-.37,;-1.28,-1.46,;-2.77,-1.06,;-3.86,-2.15,;-5.38,-1.91,;-6.08,-3.28,;-4.99,-4.37,;-3.61,-3.67,;-.67,1.1,;.58,2,;1.83,1.1,;3.29,1.57,;4.54,.67,;5.78,1.57,;5.31,3.04,;6.08,4.37,;3.77,3.04,)|
Structure:
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