Reaction Details Report a problem with these data
Target
Apelin
Ligand
BDBM610974
Substrate
n/a
Meas. Tech.
Measurement of Apelin Receptor Agonist Activity
EC50
253±n/a nM
Citation
 Ikeda, T; Kobayashi, Y; Miyoshi, N; Suzuki, O; Nagayama, T; Tsuji, T; Smith, LH; Pinkerton, AB Azole derivatives as apelin receptor agonist US Patent  US10626096 Publication Date 4/21/2020 
Target
Name:
Apelin
Synonyms:
APEL | APEL_HUMAN | APJ endogenous ligand | APLN | Apelin-13 | Apelin-28 | Apelin-31 | Apelin-36
Type:
PROTEIN
Mol. Mass.:
8579.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108275
Residue:
77
Sequence:
MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRRKFRRQRPRLSHKGPMPF
  
Inhibitor
Name:
BDBM610974
Synonyms:
4-(2,6-Dimethoxyphenyl)-3-(5-methylfuran-2-yl)-5-(methylsulfanyl)-4H-1,2,4-triazole | US10626096, Example 85
Type:
Small organic molecule
Emp. Form.:
C16H17N3O3S
Mol. Mass.:
331.389
SMILES:
COc1cccc(OC)c1-n1c(SC)nnc1-c1ccc(C)o1 |(4.31,-.37,;2.77,-.37,;2,-1.7,;2.77,-3.04,;2,-4.37,;.46,-4.37,;-.31,-3.04,;-1.85,-3.04,;-2.62,-4.37,;.46,-1.7,;-.31,-.37,;-1.85,-.37,;-2.93,-1.46,;-4.42,-1.06,;-2.32,1.1,;-1.08,2,;.17,1.1,;1.64,1.57,;2.88,.67,;4.13,1.57,;3.65,3.04,;4.42,4.37,;2.11,3.04,)|
Structure:
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