Reaction Details Report a problem with these data
Target
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Ligand
BDBM43524
Substrate
n/a
Meas. Tech.
Apoptosis Inhibition Assay
EC50
5500±n/a nM
Citation
 Zhang, Z; Wang, X; Huang, S; Jiang, X; Li, L; Zhang, Z; Han, J Apoptosis inhibitors US Patent  US11725000 Publication Date 8/15/2023 
Target
Name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Synonyms:
1.3.5.1 | Iron-sulfur subunit of complex II | SDH | SDH1 | SDHB | SDHB_HUMAN | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Type:
PROTEIN
Mol. Mass.:
31643.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117429
Residue:
280
Sequence:
MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
  
Inhibitor
Name:
BDBM43524
Synonyms:
4-(4-fluorophenyl)-2-(methylsulfonyl)-6-(trifluoromethyl)pyrimidine | 4-(4-fluorophenyl)-2-mesyl-6-(trifluoromethyl)pyrimidine | 4-(4-fluorophenyl)-2-methylsulfonyl-6-(trifluoromethyl)pyrimidine | MLS000675919 | SMR000297077 | US11725000, Compound 45 | cid_2987363
Type:
Small organic molecule
Emp. Form.:
C12H8F4N2O2S
Mol. Mass.:
320.263
SMILES:
CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1
Structure:
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