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Target
N6-adenosine-methyltransferase catalytic/non-catalytic subunit
Ligand
BDBM612844
Substrate
n/a
Meas. Tech.
METTL3/14 Methyltransferase Assay
IC50
6.10±n/a nM
Citation
 Blackaby, WP; Thomas, EJ; Hardick, DJ; Shepherd, J; Brookfield, FA; Bubert, C; Ridgill, MP Polyheterocyclic compounds as METTL3 inhibitors US Patent  US11725010 Publication Date 8/15/2023 
Target
Name:
N6-adenosine-methyltransferase catalytic/non-catalytic subunit
Synonyms:
METTL3/14 Methyltransferase
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
N6-adenosine-methyltransferase catalytic subunit
Synonyms:
2.1.1.348 | METTL3 | MT-A70 | MTA70 | MTA70_HUMAN | Methyltransferase-like protein 3 | N6-adenosine-methyltransferase 70 kDa subunit | N6-adenosine-methyltransferase catalytic subunit | hMETTL3
Type:
PROTEIN
Mol. Mass.:
64471.71
Organism:
Homo sapiens
Description:
ChEMBL_120160
Residue:
580
Sequence:
MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGGPKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRAEQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL
  
Component 2
Name:
N6-adenosine-methyltransferase non-catalytic subunit
Synonyms:
Methyltransferase-like protein 14 | hMETTL14
Type:
Protein
Mol. Mass.:
52147.33
Organism:
Human
Description:
Q9HCE5
Residue:
456
Sequence:
MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHRGGFPPR
  
Inhibitor
Name:
BDBM612844
Synonyms:
N-[[2-[[(3,3- difluorocyclobutyl) methylamino] methyl]-1H- indol-6- yl]methyl]-4- oxo-pyrido[1,2- a]pyrimidine-2- carboxamide | US11725010, Example 3
Type:
Small organic molecule
Emp. Form.:
C24H23F2N5O2
Mol. Mass.:
451.4685
SMILES:
FC1(F)CC(CNCc2cc3ccc(CNC(=O)c4cc(=O)n5ccccc5n4)cc3[nH]2)C1
Structure:
Search PDB for entries with ligand similarity: