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Target
N6-adenosine-methyltransferase catalytic/non-catalytic subunit
Ligand
BDBM613194
Substrate
n/a
Meas. Tech.
METTL3/14 Methyltransferase Assay
IC50
6.10±n/a nM
Citation
 Blackaby, WP; Thomas, EJ; Hardick, DJ; Shepherd, J; Brookfield, FA; Bubert, C; Ridgill, MP Polyheterocyclic compounds as METTL3 inhibitors US Patent  US11725010 Publication Date 8/15/2023 
Target
Name:
N6-adenosine-methyltransferase catalytic/non-catalytic subunit
Synonyms:
METTL3/14 Methyltransferase
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
N6-adenosine-methyltransferase catalytic subunit
Synonyms:
2.1.1.348 | METTL3 | MT-A70 | MTA70 | MTA70_HUMAN | Methyltransferase-like protein 3 | N6-adenosine-methyltransferase 70 kDa subunit | N6-adenosine-methyltransferase catalytic subunit | hMETTL3
Type:
PROTEIN
Mol. Mass.:
64471.71
Organism:
Homo sapiens
Description:
ChEMBL_120160
Residue:
580
Sequence:
MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGGPKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRAEQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL
  
Component 2
Name:
N6-adenosine-methyltransferase non-catalytic subunit
Synonyms:
Methyltransferase-like protein 14 | hMETTL14
Type:
Protein
Mol. Mass.:
52147.33
Organism:
Human
Description:
Q9HCE5
Residue:
456
Sequence:
MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHRGGFPPR
  
Inhibitor
Name:
BDBM613194
Synonyms:
1-[[[6-[[4- (1H-indazol- 4-yl)triazol- 1-yl]methyl]- 1H-indol-2- yl]methyl- amino]methyl] cyclobutanol | US11725010, Example 57
Type:
Small organic molecule
Emp. Form.:
C24H25N7O
Mol. Mass.:
427.5016
SMILES:
OC1(CNCc2cc3ccc(Cn4cc(nn4)-c4cccc5[nH]ncc45)cc3[nH]2)CCC1
Structure:
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