Reaction Details Report a problem with these data
Target
Substance-K receptor
Ligand
BDBM242774
Substrate
n/a
Meas. Tech.
Human NK-2 Binding Assay
Ki
>30000±n/a nM
Citation
 Hoveyda, HR; Dutheuil, G; Fraser, G N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists US Patent  US11731974 Publication Date 8/22/2023 
Target
Name:
Substance-K receptor
Synonyms:
NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:
Protein
Mol. Mass.:
44455.78
Organism:
Homo sapiens (Human)
Description:
P21452
Residue:
398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
  
Inhibitor
Name:
BDBM242774
Synonyms:
US10030025, Compound 40 | US10836768, Cpd no 40 | US11731974, Compound 40 | US9422299, 40 | US9987274, Compound 40
Type:
Small organic molecule
Emp. Form.:
C17H17FN6O2
Mol. Mass.:
356.3543
SMILES:
CCc1noc(n1)-c1nnc2C(C)N(CCn12)C(=O)c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: