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Target
Adenosine receptor A1
Ligand
BDBM616138
Substrate
n/a
Meas. Tech.
Adenosine Receptor Binding Assay
Ki
200±n/a nM
Citation
 Brown, GA; Richardson, CM; Congreve, MS; Paul, R; Andrews, SP; Mason, JS 5-AMINO-8-(4-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMIDIN-3-ONE COMPOUNDS FOR USE AGAINST CANCER US Patent  US20230271964 Publication Date 8/31/2023 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM616138
Synonyms:
US20230271964, Example 2-27
Type:
Small organic molecule
Emp. Form.:
C23H24N6O3
Mol. Mass.:
432.4751
SMILES:
COc1cc(cc(C)n1)-c1c(nc(N)n2c1nn(C[C@H]1CCCO1)c2=O)-c1ccccc1
Structure:
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