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Target
Chitinase-3-like protein 1
Ligand
BDBM616604
Substrate
n/a
Meas. Tech.
AlphaScreen assay
IC50
<100±n/a nM
Citation
 Krzeminski, L; Czestkowski, W; Mazur, M; Andryianau, G; Olejniczak, S; Piotrowicz, MC; Koralewski, R; Pluta, E; Matyszewski, K; Kowalski, M; Dymek, B; Koziel, R; Olczak, J; Golebiowski, A; Bartoszewicz, A; Krysztofiak, K YKL-40 INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS US Patent  US20230278996 Publication Date 9/7/2023 
Target
Name:
Chitinase-3-like protein 1
Synonyms:
39 kDa synovial protein | CGP-39 | Cartilage glycoprotein 39 | GP-39 | YKL-40 | hCGP-39
Type:
Protein
Mol. Mass.:
42634.54
Organism:
Human
Description:
P36222
Residue:
383
Sequence:
MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDALAAT
  
Inhibitor
Name:
BDBM616604
Synonyms:
US20230278996, Example 110.
Type:
Small organic molecule
Emp. Form.:
C24H33ClN4O
Mol. Mass.:
428.998
SMILES:
C[C@@H](O)[C@H]1CN([C@@H](Cc2ccc(Cl)cc2)CN1C)C1CCN(CC1)c1ccccn1 |r|
Structure:
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