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Target
Histone-arginine methyltransferase CARM1
Ligand
BDBM440464
Substrate
n/a
Meas. Tech.
CARM1 Enzyme Assay
IC50
<100±n/a nM
Citation
 Chesworth, R; Moradei, OM; Shapiro, G; Jin, L; Babine, RE CARM1 INHIBITORS AND USES THEREOF US Patent  US20230279020 Publication Date 9/7/2023 
Target
Name:
Histone-arginine methyltransferase CARM1
Synonyms:
CARM1 | CARM1_HUMAN | Coactivator-associated arginine methyltransferase 1 | Coactivator-associated arginine methyltransferase 1 (CARM1) | PRMT4 | Protein arginine N-methyltransferase 4 | Protein arginine methyltransferase 4 (PRMT4)
Type:
Protein
Mol. Mass.:
65855.47
Organism:
Homo sapiens (Human)
Description:
Q86X55
Residue:
608
Sequence:
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSHEDVCVFKCSVSRETECSRVGKQSFIITLGCNSVLIQFATPNDFCSFYNILKTCRGHTLERSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDFKDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTDRIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSGNMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDEYFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGLVHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDTLSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRYTGTTPSPPPGSHYTSPSENMWNTGSTYNLSSGMAVAGMPTAYDLSSVIASGSSVGHNNLIPLANTGIVNHTHSRMGSIMSTGIVQGSSGAQGSGGGSTSAHYAVNSQFTMGGPAISMASPMSIPTNTMHYGS
  
Inhibitor
Name:
BDBM440464
Synonyms:
US10633389, Example 129-3 | US20230279020, Example 129-3
Type:
Small organic molecule
Emp. Form.:
C26H32Cl2N6O5
Mol. Mass.:
579.475
SMILES:
CCOC(=O)N1CC[C@H](C1)Nc1nc(nc(-c2c(C)noc2C)c1Cl)-c1cc(OC[C@H](O)CNC)ccc1Cl |r,wD:8.10,30.33,(11.38,-4.02,;9.88,-3.7,;9.4,-2.23,;7.89,-1.91,;6.86,-3.05,;7.42,-.45,;8.32,.8,;7.42,2.05,;5.95,1.57,;5.95,.03,;4.62,2.34,;3.29,1.57,;1.95,2.34,;.62,1.57,;.62,.03,;1.95,-.74,;1.95,-2.28,;3.2,-3.19,;4.53,-2.42,;2.72,-4.65,;1.18,-4.65,;.71,-3.19,;-.63,-2.42,;3.29,.03,;4.62,-.74,;-.71,2.34,;-2.05,1.57,;-3.38,2.34,;-4.72,1.57,;-6.05,2.34,;-7.38,1.57,;-7.38,.03,;-8.72,2.34,;-10.05,1.57,;-11.38,2.34,;-3.38,3.88,;-2.05,4.65,;-.71,3.88,;.62,4.65,)|
Structure:
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