Reaction Details
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Report a problem with these dataTarget
GTPase KRas [G12D]
Ligand
BDBM573228
Substrate
n/a
Meas. Tech.
KRas G12D Surface Plasmon Resonance (SPR) Binding Assay
Kd
15593±n/a nM
Citation
Wang, X; Burns, AC; Christensen, JG; Ketcham, JM; Lawson, JD; Marx, MA; Smith, CR; Allen, S; Blake, JF; Chicarelli, MJ; Dahlke, JR; Dai, D; Fell, JB; Fischer, JP; Mejia, MJ; Newhouse, B; Nguyen, P; O''Leary, JM; Pajk, S; Rodriguez, ME; Savechenkov, P; Tang, TP; Vigers, GP; Zhao, Q; Kahn, DR; Gaudino, J; Hilton, MC KRAS G12D INHIBITORS US Patent US20230279025 Publication Date 9/7/2023 More Info.:
Target
Name:
GTPase KRas [G12D]
Synonyms:
GTPase KRas (G12D) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21713.12
Organism:
Homo sapiens (Human)
Description:
P01116[G12D]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
Inhibitor
Name:
BDBM573228
Synonyms:
US11453683, Example 88 | US20230279025, Example 88
Type:
Small organic molecule
Emp. Form.:
C27H28FN9O
Mol. Mass.:
513.5693
SMILES:
Cc1ccc2[nH]ncc2c1-c1ncc2c(nc(OCCc3nccn3C)nc2c1F)N1CC2CCC(C1)N2 |(-3.95,-5,;-5.28,-4.23,;-6.61,-5,;-7.95,-4.23,;-7.95,-2.69,;-9.09,-1.66,;-8.47,-.26,;-6.93,-.42,;-6.61,-1.93,;-5.28,-2.69,;-3.95,-1.93,;-3.95,-.38,;-2.61,.38,;-1.28,-.38,;.05,.38,;1.39,-.38,;1.39,-1.93,;2.72,-2.69,;4.06,-1.93,;5.39,-2.69,;6.72,-1.93,;8.19,-2.4,;9.09,-1.15,;8.19,.09,;6.72,-.38,;5.3,.2,;.05,-2.69,;-1.28,-1.93,;-2.61,-2.69,;-2.61,-4.23,;.05,1.93,;-1.28,2.69,;-1.28,4.23,;-.6,3.39,;.78,3.39,;1.39,4.23,;1.39,2.69,;.05,5,)|
Structure:
