Reaction Details Report a problem with these data
Target
Cytochrome P450 2D6
Ligand
BDBM617049
Substrate
n/a
Meas. Tech.
CYP P450 Enzyme Inhibition
IC50
>50000±n/a nM
Citation
 Shapiro, G; Flood, DG Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders US Patent  US11752155 Publication Date 9/12/2023 
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM617049
Synonyms:
US11752155, Compound III-E1-22.1B'
Type:
Small organic molecule
Emp. Form.:
C20H22F2N4O2
Mol. Mass.:
388.4111
SMILES:
FC1(F)CN(CC[C@@H]1CNc1ncccn1)C(=O)OC1Cc2ccccc2C1 |r|
Structure:
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