Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E [28-217]
Ligand
BDBM617058
Substrate
n/a
Meas. Tech.
Human eIF4E/4G2 Binding Assay
IC50
<1000±n/a nM
Citation
 Vandeusen, CL; Walts, AE; Or, YS EIF4E inhibitors and uses thereof US Patent  US11753403 Publication Date 9/12/2023 
Target
Name:
Eukaryotic translation initiation factor 4E [28-217]
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22131.40
Organism:
Homo sapiens (Human)
Description:
aa 28-217
Residue:
190
Sequence:
VANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
  
Inhibitor
Name:
BDBM617058
Synonyms:
US11753403, Compound I-3
Type:
Small organic molecule
Emp. Form.:
C23H24Cl2N2O3S
Mol. Mass.:
479.419
SMILES:
COc1ccccc1CC(CNc1nc(c(s1)C(C)C)-c1ccc(Cl)c(Cl)c1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: