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Target
Interleukin-17F
Ligand
BDBM617535
Substrate
n/a
Meas. Tech.
AlphaLISA Assay
IC50
63.1±n/a nM
Citation
 MARTIN, BP; WESTERMANN, J; KERN, OT; HOLMES, AJ; MORRISON, A; KICZUN, M; AL MASRI, M; SMITH, A; HUXLEY, A IL-17A MODULATORS US Patent  US20230286943 Publication Date 9/14/2023 
Target
Name:
Interleukin-17F
Synonyms:
Cytokine ML-1 | IL17F | IL17F_HUMAN | il-17f
Type:
Enzyme Catalytic Domain
Mol. Mass.:
18053.35
Organism:
Homo sapiens (Human)
Description:
Q96PD4
Residue:
163
Sequence:
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
  
Inhibitor
Name:
BDBM617535
Synonyms:
US20230286943, Example 3
Type:
Small organic molecule
Emp. Form.:
C27H30N6O3
Mol. Mass.:
486.5655
SMILES:
C[C@H]1CC[C@@H](CC1)[C@H](NC(=O)c1ccnn1C)C(=O)Nc1ccc(cc1)-c1c[nH]c(=O)c2[nH]ccc12 |r,wU:1.0,wD:7.8,4.4,(2.78,6.61,;2.78,5.07,;4.12,4.3,;4.12,2.76,;2.78,1.99,;1.45,2.76,;1.45,4.3,;2.78,.45,;4.12,-.32,;5.45,.45,;5.45,1.99,;6.78,-.32,;6.94,-1.85,;8.45,-2.17,;9.22,-.84,;8.19,.31,;8.51,1.81,;1.45,-.32,;1.45,-1.86,;.11,.45,;-1.22,-.32,;-2.55,.45,;-3.89,-.32,;-3.89,-1.86,;-2.55,-2.63,;-1.22,-1.86,;-5.22,-2.63,;-6.55,-1.86,;-7.89,-2.63,;-7.89,-4.17,;-9.22,-4.94,;-6.55,-4.94,;-6.23,-6.45,;-4.7,-6.61,;-4.08,-5.2,;-5.22,-4.17,)|
Structure:
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