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Target
LIM domain kinase 2
Ligand
BDBM622485
Substrate
n/a
Meas. Tech.
In Vitro Assay
Ki
2.89±n/a nM
Citation
 ROUTIER, S; BENEDETTI, H; LÉE-MÉHEUST, B; BONNET, P; PLÉ, K; ACI-SÈCHE, S; RUCHAUD, S; BRAKA, A; CHAMPIRÉ, A; ANDRES, C; VOURC''H, P 4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER US Patent  US20230312576 Publication Date 10/5/2023 
Target
Name:
LIM domain kinase 2
Synonyms:
LIMK2 | LIMK2_HUMAN
Type:
PROTEIN
Mol. Mass.:
72238.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1514398
Residue:
638
Sequence:
MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP
  
Inhibitor
Name:
BDBM622485
Synonyms:
US20230312576, Compound 198
Type:
Small organic molecule
Emp. Form.:
C26H25N7O3
Mol. Mass.:
483.5218
SMILES:
CNC(=O)c1cc(Oc2cccc(NC(=O)N3CCC(=CC3)c3ncnc4[nH]cc(C)c34)c2)ccn1 |c:19|
Structure:
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