Target
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
Ligand
BDBM622511
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
189±n/a nM
Citation
 Yu, CSun, ZLiu, BZhang, C 1H-IMIDAZO [4,5-H] QUINAZOLINE COMPOUND AS NOVEL SELECTIVE FLT3 INHIBITORS US Patent  US20230312583 Publication Date 10/5/2023 
Target
Name:
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
Synonyms:
CDK6/Cyclin D1
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Component 2
Name:
G1/S-specific cyclin-D1
Synonyms:
CCND1_MOUSE | Ccnd1 | Cyclin D1 | Cyl-1
Type:
Enzyme Subunit
Mol. Mass.:
33418.84
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
295
Sequence:
MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQKEIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQTIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGEVEEEAGLACTPTDVRDVDI
  
Inhibitor
Name:
BDBM622511
Synonyms:
US20230312583, Compound I-7
Type:
Small organic molecule
Emp. Form.:
C24H30N8O
Mol. Mass.:
446.548
SMILES:
CCOc1cc(Nc2ncc3ccc4ncn(C(C)C)c4c3n2)ncc1N1CCN(C)CC1
Structure:
Search PDB for entries with ligand similarity: