Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit beta-1
Ligand
BDBM625638
Substrate
n/a
Meas. Tech.
Steroid Inhibition of TBPS Binding
IC50
<100±n/a nM
Citation
 Blanco-Pillado, MJ; SALITURO, FG; MORNINGSTAR, ML NEUROACTIVE STEROIDS AND THEIR METHODS OF USE US Patent  US20230322846 Publication Date 10/12/2023 
Target
Name:
Gamma-aminobutyric acid receptor subunit beta-1
Synonyms:
GABA(A) receptor subunit beta-1
Type:
Protein
Mol. Mass.:
54082.33
Organism:
Rat
Description:
P15431
Residue:
474
Sequence:
MWTVQNRESLGLLSFPVMVAMVCCAHSSNEPSNMSYVKETVDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTGVSDPKATMYSYDSASIQYRKPLSSREGFGRGLDRHGVPGKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH
  
Inhibitor
Name:
BDBM625638
Synonyms:
US20230322846, Example 24
Type:
Small organic molecule
Emp. Form.:
C28H41NO2
Mol. Mass.:
423.6306
SMILES:
C[C@@H](NC(=O)c1ccccc1)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@](C)(O)CC[C@@H]4[C@H]3CC[C@]12C |r|
Structure:
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