Reaction Details Report a problem with these data
Target
Transcriptional enhancer factor TEF-1
Ligand
BDBM626338
Substrate
n/a
Meas. Tech.
HTRF Assay
IC50
160±n/a nM
Citation
 Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent  US11787775 Publication Date 10/17/2023 
Target
Name:
Transcriptional enhancer factor TEF-1
Synonyms:
NTEF-1 | Protein GT-IIC | TCF-13 | TCF13 | TEA domain family member 1 | TEAD-1 | TEAD1 | TEAD1_HUMAN | TEF1 | Transcription factor 13 | Transcriptional enhancer factor TEF-1
Type:
PROTEIN
Mol. Mass.:
47954.57
Organism:
Homo sapiens
Description:
ChEMBL_109666
Residue:
426
Sequence:
MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGAPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPASAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVTSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
  
Inhibitor
Name:
BDBM626338
Synonyms:
2-[[[7-cyano-4-[4-(1,1- difluoroethyl)phenyl]-1,3- benzothiazol-6- yl]amino]methyl]prop-2-enoic acid | US11787775, Compound 24
Type:
Small organic molecule
Emp. Form.:
C20H15F2N3O2S
Mol. Mass.:
399.414
SMILES:
CC(F)(F)c1ccc(cc1)-c1cc(NCC(=C)C(O)=O)c(C#N)c2scnc12
Structure:
Search PDB for entries with ligand similarity: