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Target
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
Ligand
BDBM626330
Substrate
n/a
Meas. Tech.
HTRF Assay
EC50
250±n/a nM
Citation
 Zbieg, JR; Beroza, PP Therapeutic compounds and methods of use US Patent  US11787775 Publication Date 10/17/2023 
Target
Name:
Transcriptional enhancer factor TEF-3/Isoform 5 of Transcriptional coactivator [50-100]
Synonyms:
TEAD4 YAP50-100 combined
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Transcriptional enhancer factor TEF-3
Synonyms:
RTEF1 | TCF13L1 | TEA domain family member 4 | TEAD-4 | TEAD4 | TEAD4_HUMAN | TEF3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | Transcriptional enhancer factor TEF-3
Type:
PROTEIN
Mol. Mass.:
48333.01
Organism:
Homo sapiens
Description:
ChEMBL_118073
Residue:
434
Sequence:
MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
  
Component 2
Name:
Isoform 5 of Transcriptional coactivator [50-100]
Synonyms:
Transcriptional coactivator YAP1 (50-100) | YAP1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5701.47
Organism:
Homo sapiens (Human)
Description:
P46937-5[50-100]
Residue:
51
Sequence:
AGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPE
  
Inhibitor
Name:
BDBM626330
Synonyms:
2-[[[4-cyano-7-[4- (trifluoromethyl)phenyl]-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2-enoic acid | US11787775, Compound 15
Type:
Small organic molecule
Emp. Form.:
C20H15F3N2O3
Mol. Mass.:
388.3399
SMILES:
OC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(cc1)C(F)(F)F
Structure:
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