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Target
Lysyl oxidase homolog 2
Ligand
BDBM461386
Substrate
n/a
Meas. Tech.
LOXL2 AmineOxidase Activity Assay
IC50
<300±0 nM
Citation
 Bain, G; Evans, JF; Mackenna, DA; Hutchinson, JH Uses of a lysyl oxidase-like 2 inhibitor US Patent  US11793797 Publication Date 10/24/2023 
Target
Name:
Lysyl oxidase homolog 2
Synonyms:
1.4.3.13 | LOXL2 | LOXL2_HUMAN | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 | Lysyl oxidase-related protein 2 | Lysyl oxidase-related protein WS9-14
Type:
PROTEIN
Mol. Mass.:
86721.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115990
Residue:
774
Sequence:
MERPLCSHLCSCLAMLALLSPLSLAQYDSWPHYPEYFQQPAPEYHQPQAPANVAKIQLRLAGQKRKHSEGRVEVYYDGQWGTVCDDDFSIHAAHVVCRELGYVEAKSWTASSSYGKGEGPIWLDNLHCTGNEATLAACTSNGWGVTDCKHTEDVGVVCSDKRIPGFKFDNSLINQIENLNIQVEDIRIRAILSTYRKRTPVMEGYVEVKEGKTWKQICDKHWTAKNSRVVCGMFGFPGERTYNTKVYKMFASRRKQRYWPFSMDCTGTEAHISSCKLGPQVSLDPMKNVTCENGLPAVVSCVPGQVFSPDGPSRFRKAYKPEQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGSAKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDAGVRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERNGSLVWGMVCGQNWGIVEAMVVCRQLGLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAGVACSETAPDLVLNAEMVQQTTYLEDRPMFMLQCAMEENCLSASAAQTDPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKNYECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEVAESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ
  
Inhibitor
Name:
BDBM461386
Synonyms:
US10774069, Compound Rac-1 | US11072585, Example 121 | US11459309, Compound Ent-1 | US11793797, Compound Ent-1
Type:
Small organic molecule
Emp. Form.:
C18H17F4N3O3
Mol. Mass.:
399.3395
SMILES:
NCc1cc(Oc2cccc(c2)C(=O)N2C[C@H](O)[C@@H](F)C2)nc(c1)C(F)(F)F |r|
Structure:
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