Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM631222
Substrate
n/a
Meas. Tech.
MAGL Inhibitory Activity Assay
IC50
1.000±n/a nM
Citation
Bell, C; Benz, J; Gobbi, L; Grether, U; Groebke Zbinden, K; Hornsperger, B; Kocer, B; Kroll, C; Kuhn, B; Lutz, MD; O''Hara, F; Richter, H; Ritter, M; Rombach, D; Kuratli, M Heterocyclic compounds as monoacylglycerol lipase inhibitors US Patent US11802133 Publication Date 10/31/2023
More Info.:
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
Inhibitor
Name:
BDBM631222
Synonyms:
(4aR,8aS)-6-(4-((2-chloro-4-fluorophenoxy)methyl)-4-methylpiperidine-1-carbonyl)hexahydro-2H-pyrido[4,3-b][1,4]oxazin-3(4H)-one | US11802133, Example 79
Type:
Small organic molecule
Emp. Form.:
C21H27ClFN3O4
Mol. Mass.:
439.908
SMILES:
CC1(COc2ccc(F)cc2Cl)CCN(CC1)C(=O)N1CC[C@@H]2OCC(=O)N[C@@H]2C1 |r|