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Target
Retinol-binding protein
Ligand
BDBM50553539
Substrate
n/a
Meas. Tech.
In Vitro Binding of Compounds to RBP4
IC50
130±n/a nM
Citation
 Petrukhin, K; Racz, B; Varadi, A; Muthuraman, P; Raja, A; Cioffi, CL BISPECIFIC ANTAGONISTS OF RETINOL-BINDING PROTEIN 4 THAT STABILIZE TRANSTHYRETIN TETRAMERS, THEIR PREPARATION, AND USE IN THE TREATMENT OF COMMON AGE-RELATED COMORBIDITIES US Patent  US20230348415 Publication Date 11/2/2023 
Target
Name:
Retinol-binding protein
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
22972.55
Organism:
Human
Description:
Q5VY30
Residue:
199
Sequence:
MNYSKIPAQVDLRRQTERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM50553539
Synonyms:
CHEMBL4761230 | US20230348415, Compound (+-)-88
Type:
Small organic molecule
Emp. Form.:
C18H17F4N3O3
Mol. Mass.:
399.3395
SMILES:
Cc1cc(nc(n1)N1CCC(COc2cc(F)ccc2C(F)(F)F)C1)C(O)=O
Structure:
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