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Target
Retinol-binding protein
Ligand
BDBM50553541
Substrate
n/a
Meas. Tech.
In Vitro Binding of Compounds to RBP4
IC50
>3000±n/a nM
Citation
 Petrukhin, K; Racz, B; Varadi, A; Muthuraman, P; Raja, A; Cioffi, CL BISPECIFIC ANTAGONISTS OF RETINOL-BINDING PROTEIN 4 THAT STABILIZE TRANSTHYRETIN TETRAMERS, THEIR PREPARATION, AND USE IN THE TREATMENT OF COMMON AGE-RELATED COMORBIDITIES US Patent  US20230348415 Publication Date 11/2/2023 
Target
Name:
Retinol-binding protein
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
22972.55
Organism:
Human
Description:
Q5VY30
Residue:
199
Sequence:
MNYSKIPAQVDLRRQTERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM50553541
Synonyms:
CHEMBL4741334 | US20230348415, Compound (+-)-90
Type:
Small organic molecule
Emp. Form.:
C19H20F3N3O4
Mol. Mass.:
411.375
SMILES:
COc1ccc(c(OCC2CCN(C2)c2nc(C)cc(n2)C(O)=O)c1)C(F)(F)F
Structure:
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