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Target
Galectin-1
Ligand
BDBM632511
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
418±n/a nM
Citation
 BOLLI, M; GATFIELD, J; GRISOSTOMI, C; REMEN, L; SAGER, C; ZUMBRUNN, C GALECTIN-3 INHIBITING 2-HYDROXYCYCLOALKANE-1-CARBAMOYL DERIVATIVES US Patent  US20230348442 Publication Date 11/2/2023 
Target
Name:
Galectin-1
Synonyms:
14 kDa lectin | Galaptin | HPL | LEG1_HUMAN | LGALS1 | Lactose-binding lectin 1 | Lectin galactoside-binding soluble 1 | Putative MAPK-activating protein PM12
Type:
beta galactoside-binding protein
Mol. Mass.:
14713.53
Organism:
Homo sapiens (Human)
Description:
P09382
Residue:
135
Sequence:
MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
  
Inhibitor
Name:
BDBM632511
Synonyms:
(2R,3R,4S,5R,6R)-4-(4-(4-bromo-2,3-difluorophenyl)-1H-1,2,3-triazol-1-yl)- N-(3-cyano-5-fluorophenyl)-5-hydroxy-N-((1S,2S)-2-hydroxycyclopentyl)-6- (hydroxymethyl)-3-methoxytetrahydro-2H-pyran-2-carboxamide | US20230348442, Example 1.12.7
Type:
Small organic molecule
Emp. Form.:
C28H27BrF3N5O6
Mol. Mass.:
666.443
SMILES:
CO[C@H]1[C@@H](O[C@H](CO)[C@H](O)[C@@H]1n1cc(nn1)-c1ccc(Br)c(F)c1F)C(=O)N([C@H]1CCC[C@@H]1O)c1cc(F)cc(c1)C#N
Structure:
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