Reaction Details Report a problem with these data
Target
Myelin transcription factor 1
Ligand
BDBM633007
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
2.00±n/a nM
Citation
 SZYCHOWSKI, J; LIU, B; DIETRICH, E; PERRYMAN, A; CRANE, SN; TRUONG, VL; ABDOLI, A; BOUCHARD, A QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME US Patent  US20230348456 Publication Date 11/2/2023 
Target
Name:
Myelin transcription factor 1
Synonyms:
KIAA0835 | KIAA1050 | MTF1 | MYT1 | MYT1_HUMAN | MYTI | Myelin transcription factor I | PLPB1
Type:
PROTEIN
Mol. Mass.:
122258.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942118
Residue:
1121
Sequence:
MSLENEDKRARTRSKALRGPPETTAADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEGAEAEHLVSKRKSHPLKLALDEGYGVDSDGSEDTEVKDASVSDESEGTLEGAEAETSGQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPAEQSQLGLGEPGKAAKPLDTVRKSYYSKDPSRAEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGSLNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVSTLTDMYSNQDPENKDLLESIKQAVRGIQV
  
Inhibitor
Name:
BDBM633007
Synonyms:
US20230348456, Compound 27
Type:
Small organic molecule
Emp. Form.:
C27H24N6O2
Mol. Mass.:
464.5185
SMILES:
Cc1ccc(O)c(C)c1-c1cc(-c2cnn(c2)C2CC2)c2nc([nH]c(=O)c2c1N)-c1ccncc1 |(4.72,1.85,;4.96,3.03,;6.18,3.86,;6.94,5.01,;5.67,5.21,;6.07,6.55,;4.25,4.46,;3.18,4.77,;3.73,3.31,;2.4,2.54,;2.4,1,;1.07,.23,;1.07,-1.31,;2.31,-2.21,;1.84,-3.68,;.3,-3.68,;-.18,-2.21,;-.47,-5.01,;-1.81,-5.78,;-.47,-6.55,;-.27,1,;-1.6,.23,;-2.93,1,;-2.93,2.54,;-1.6,3.31,;-1.6,4.85,;-.27,2.54,;1.07,3.31,;1.07,4.85,;-4.27,.23,;-5.6,1,;-6.94,.23,;-6.94,-1.31,;-5.6,-2.08,;-4.27,-1.31,)|
Structure:
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