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Target
Myelin transcription factor 1
Ligand
BDBM633031
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
5.00±n/a nM
Citation
 SZYCHOWSKI, J; LIU, B; DIETRICH, E; PERRYMAN, A; CRANE, SN; TRUONG, VL; ABDOLI, A; BOUCHARD, A QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME US Patent  US20230348456 Publication Date 11/2/2023 
Target
Name:
Myelin transcription factor 1
Synonyms:
KIAA0835 | KIAA1050 | MTF1 | MYT1 | MYT1_HUMAN | MYTI | Myelin transcription factor I | PLPB1
Type:
PROTEIN
Mol. Mass.:
122258.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942118
Residue:
1121
Sequence:
MSLENEDKRARTRSKALRGPPETTAADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEGAEAEHLVSKRKSHPLKLALDEGYGVDSDGSEDTEVKDASVSDESEGTLEGAEAETSGQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPAEQSQLGLGEPGKAAKPLDTVRKSYYSKDPSRAEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGSLNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVSTLTDMYSNQDPENKDLLESIKQAVRGIQV
  
Inhibitor
Name:
BDBM633031
Synonyms:
US20230348456, Compound 52
Type:
Small organic molecule
Emp. Form.:
C32H29N7O3
Mol. Mass.:
559.6178
SMILES:
Nc1c(cc(-c2cccc(OCCN3CCOCC3)c2)c2nc([nH]c(=O)c12)-c1ccncc1)-c1cccc2[nH]ncc12
Structure:
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