Reaction Details Report a problem with these data
Target
Myelin transcription factor 1
Ligand
BDBM633113
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
5.00±n/a nM
Citation
 SZYCHOWSKI, J; LIU, B; DIETRICH, E; PERRYMAN, A; CRANE, SN; TRUONG, VL; ABDOLI, A; BOUCHARD, A QUINAZOLINONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME US Patent  US20230348456 Publication Date 11/2/2023 
Target
Name:
Myelin transcription factor 1
Synonyms:
KIAA0835 | KIAA1050 | MTF1 | MYT1 | MYT1_HUMAN | MYTI | Myelin transcription factor I | PLPB1
Type:
PROTEIN
Mol. Mass.:
122258.96
Organism:
Homo sapiens (Human)
Description:
ChEMBL_942118
Residue:
1121
Sequence:
MSLENEDKRARTRSKALRGPPETTAADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEGAEAEHLVSKRKSHPLKLALDEGYGVDSDGSEDTEVKDASVSDESEGTLEGAEAETSGQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPAEQSQLGLGEPGKAAKPLDTVRKSYYSKDPSRAEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGSLNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVSTLTDMYSNQDPENKDLLESIKQAVRGIQV
  
Inhibitor
Name:
BDBM633113
Synonyms:
US20230348456, Compound 134
Type:
Small organic molecule
Emp. Form.:
C24H22N4O2
Mol. Mass.:
398.4571
SMILES:
Cc1ccc(O)c(C)c1-c1cc(C2CC2)c2nc([nH]c(=O)c2c1N)-c1ccncc1 |(2,4.13,;3.33,3.36,;4.67,4.13,;6,3.36,;6,1.82,;7.34,1.05,;4.67,1.05,;4.67,-.49,;3.33,1.82,;2,1.05,;2,-.49,;.67,-1.26,;.67,-2.8,;-.1,-4.13,;1.44,-4.13,;-.67,-.49,;-2,-1.26,;-3.33,-.49,;-3.33,1.05,;-2,1.82,;-2,3.36,;-.67,1.05,;.67,1.82,;.67,3.36,;-4.67,-1.26,;-6,-.49,;-7.34,-1.26,;-7.34,-2.8,;-6,-3.57,;-4.67,-2.8,)|
Structure:
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