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Target
Protein-lysine 6-oxidase
Ligand
BDBM633181
Substrate
n/a
Meas. Tech.
Inhibition of LOX and LOXL1-4
IC50
>300±n/a nM
Citation
 Findlay, AD; Turner, CI; Deodhar, M; Foot, JS; Jarolimek, W; Schilter Sambade, H; Zhou, W; Perryman, LA BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF US Patent  US20230349907 Publication Date 11/2/2023 
Target
Name:
Protein-lysine 6-oxidase
Synonyms:
1.4.3.13 | LOX | LYOX_BOVIN | Lysyl oxidase | Protein-lysine 6-oxidase | Protein-lysine 6-oxidase, long form | Protein-lysine 6-oxidase, short form
Type:
PROTEIN
Mol. Mass.:
47015.72
Organism:
Bos taurus
Description:
ChEMBL_118967
Residue:
417
Sequence:
MRFAWTALLGSLQLCALVRCAPPAASHRQPPREQAAAPGAWRQKIQWENNGQVFSLLSLGSQYQPQRRRDPGATAPGAANATAPQMRTPILLLRNNRTAAARVRTAGPSAAAAGRPRPAARHWFQAGYSTSGAHDAGTSRADNQTAPGEVPTLSNLRPPNRVEVDGMVGDDPYNPYKYTDDNPYYNYYDTYERPRPGSRYRPGYGTGYFQYGLPDLVPDPYYIQASTYVQKMAMYNLRCAAEENCLASSAYRDVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDASTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYNADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYSNNVVRCEIRYTGHHAYASGCTISPY
  
Inhibitor
Name:
BDBM633181
Synonyms:
1-((Z)-4-amino-2-fluorobut-2-en-1-yl)-3-(3-(N,N-dimethylsulfamoyl)phenyl)-2-methyl-N-(5-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)pentyl)-1H-indole-5-carboxamide | US20230349907, Compound 1-2
Type:
Small organic molecule
Emp. Form.:
C38H52FN7O5S2
Mol. Mass.:
769.992
SMILES:
CN(C)S(=O)(=O)c1ccc(Cc2c(C)n(C\C(F)=C\CN)c3ccc(cc23)C(=O)NCCCCCNC(=O)CCCC[C@@H]2SC[C@@H]3NC(=O)N[C@H]23)cc1 |r|
Structure:
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