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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM634528
Substrate
n/a
Meas. Tech.
Measurement of Human IRAK-4 Inhibitory Activity
IC50
0.930±n/a nM
Citation
 ITO, T; TAKASHIMA, M; ATOBE, M; ARAI, K; TOYAMA, T; YOSHII, Y; POTTER, AJ; MADDOX, DP; RAY, S; FOLOPPE, N MACROCYCLIC COMPOUND US Patent  US20230357271 Publication Date 11/9/2023 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM634528
Synonyms:
US20230357271, Example a-02-12
Type:
Small organic molecule
Emp. Form.:
C23H25N5O4
Mol. Mass.:
435.4757
SMILES:
OCc1ncc(cn1)-c1ccc2ncc3N[C@H]4CCN[C@@H](C4)C(=O)OCCCOc1c2c3
Structure:
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