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Target
Cell division cycle 7-related protein kinase
Ligand
BDBM636623
Substrate
n/a
Meas. Tech.
CDC7 Kinase Biochemical Assay
IC50
<1±n/a nM
Citation
HUANG, X; MONDAL, S; GHANAKOTA, P; BOYLES, N; FRYE, L; LEVINSON, A; GREENWOOD, JR; BOS, P; BHAT, S; GERASYUTO, A; TANG, H HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER US Patent US20230365584 Publication Date 11/16/2023
More Info.:
Target
Name:
Cell division cycle 7-related protein kinase
Synonyms:
CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7
Type:
Protein
Mol. Mass.:
63908.16
Organism:
Homo sapiens (Human)
Description:
O00311
Residue:
574
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
Inhibitor
Name:
BDBM636623
Synonyms:
7-(azetidin-1-ylmethyl)- 10,10-difluoro-2-(1H-pyrazol-4-yl)- 12-oxa-3-thia-6-azatricyclo [6.4.1.04,13]trideca-1,4(13),7-trien-5- one | US20230365584, Compound 44.
Type:
Small organic molecule
Emp. Form.:
C17H16F2N4O2S
Mol. Mass.:
378.396
SMILES:
FC1(F)COc2c(sc3c2c(C1)c(CN1CCC1)[nH]c3=O)-c1cn[nH]c1