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Target
Cell division cycle 7-related protein kinase
Ligand
BDBM636638
Substrate
n/a
Meas. Tech.
CDC7 Kinase Biochemical Assay
IC50
<1±n/a nM
Citation
 HUANG, X; MONDAL, S; GHANAKOTA, P; BOYLES, N; FRYE, L; LEVINSON, A; GREENWOOD, JR; BOS, P; BHAT, S; GERASYUTO, A; TANG, H HETEROCYCLIC PERICONDENSED CDC7 KINASE INHIBITORS FOR THE TREATMENT OF CANCER US Patent  US20230365584 Publication Date 11/16/2023 
Target
Name:
Cell division cycle 7-related protein kinase
Synonyms:
CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7
Type:
Protein
Mol. Mass.:
63908.16
Organism:
Homo sapiens (Human)
Description:
O00311
Residue:
574
Sequence:
MEASLGIQMDEPMAFSPQRDRFQAEGSLKKNEQNFKLAGVKKDIEKLYEAVPQLSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLTVAGGQDNVMGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKSHIITGNKIPLSGPVPKELDQQSTTKASVKRPYTNAQIQIKQGKDGKEGSVGLSVQRSVFGERNFNIHSSISHESPAVKLMKQSKTVDVLSRKLATKKKAISTKVMNSAVMRKTASSCPASLTCDCYATDKVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHASHQPAISEKTDHKASCLVQTPPGQYSGNSFKKGDSNSCEHCFDEYNTNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL
  
Inhibitor
Name:
BDBM636638
Synonyms:
(S)-5-(1-cyclopropyl-1- hydroxyethyl)-1-(1H-pyrazol-4-yl)- 4,6,7,8-tetrahydro-3H-9-oxa-2-thia-4- azabenzo[cd]azulen-3-one | US20230365584, Compound 59.
Type:
Small organic molecule
Emp. Form.:
C18H19N3O3S
Mol. Mass.:
357.427
SMILES:
C[C@](O)(C1CC1)c1[nH]c(=O)c2sc(-c3cn[nH]c3)c3OCCCc1c23 |r|
Structure:
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