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Target
S-adenosylmethionine synthase isoform type-2
Ligand
BDBM637532
Substrate
n/a
Meas. Tech.
Measurement of Mat2A inhibition is performed in 384 well format absorbance-based assay
IC50
13.0±n/a nM
Citation
 BELL, AS; BESNARD, J; BRADLEY, AR; GREEN, L; HAAP, W; KOCER, B; KUGLSTATTER, A; LUCAS, X; MATTEI, P; MAZUNIN, D; RIEMER, C; VAN HOORN, WP PYRAZOLEAMIDE DERIVATIVES US Patent  US20230382911 Publication Date 11/30/2023 
Target
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AMS2 | AdoMet synthase 2 | MAT 2 | MAT-II | MAT2A | MATA2 | METK2_HUMAN | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II
Type:
Protein
Mol. Mass.:
43659.65
Organism:
Human
Description:
P31153
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQISDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAVDYQKVVREAVKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVLPIRVHTIVISVQHDEEVCLDEMRDALKEKVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKKNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM637532
Synonyms:
(3-amino-6-((1rs,2RS,3SR)-2,3- dimethylcyclopropyl)-1H- pyrazolo[3,4-b]pyridin-1-yl)(2- methoxyphenyl)methanone | US20230382911, Example 44
Type:
Small organic molecule
Emp. Form.:
C19H20N4O2
Mol. Mass.:
336.3877
SMILES:
COc1ccccc1C(=O)n1nc(N)c2ccc(nc12)[C@@H]1[C@@H](C)[C@H]1C |r|
Structure:
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