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Target
Voltage-dependent calcium channel gamma-2 subunit
Ligand
BDBM311783
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
IC50
0.316±n/a nM
Citation
 Ameriks, MK; Laforteza, BN; Lebold, TP; Ravula, S; Savall, BM; Shireman, BT Fused azaheterocyclic compounds and their use as AMPA receptor modulators US Patent  US10155769 Publication Date 12/18/2018 
Target
Name:
Voltage-dependent calcium channel gamma-2 subunit
Synonyms:
CACNG2 | CCG2_HUMAN | Neuronal voltage-gated calcium channel gamma-2 subunit | TARP gamma-2 | Transmembrane AMPAR regulatory protein gamma-2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35977.54
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
323
Sequence:
MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKENKDSLHSNTANRRTTPV
  
Inhibitor
Name:
BDBM311783
Synonyms:
5-(2,7-Bis(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-7-chloroindolin-2-one | US10155769, Example 21
Type:
Small organic molecule
Emp. Form.:
C16H7ClF6N4O
Mol. Mass.:
420.696
SMILES:
FC(F)(F)c1nc2c(-c3cc4CC(=O)Nc4c(Cl)c3)c(ccn2n1)C(F)(F)F
Structure:
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